Regenerative Potential of CD200- Subpopulations of Hair Follicle Bulge

April 2026 in “ Frontiers in Cell and Developmental Biology ”

Ting Sun, Sayuri Hamano, Jing Chen, Lichen Ling, J I N Y I Lin, Lei Yan, Tatsuto Kageyama, Fuyue Wu, Zheng Lin Tan, W Z Wu, Junji Fukuda

CD200- hair follicle bulge epithelial stem cells KRT15 transcriptomic profiling hair regeneration bulge cell-based approaches

TLDR CD200- cells in hair follicles have a higher ability to regenerate hair.

This study explores the regenerative potential of CD200- subpopulations within the human hair follicle bulge, traditionally known for its epithelial stem cells. By examining CD200- and KRT15-expressing cells through phenotypic characterization, transcriptomic profiling, and in vivo assays, researchers found that CD200- cells demonstrated a higher capacity for hair regeneration. The findings suggest that reduced CD200 expression correlates with enhanced regenerative abilities, offering new insights into optimizing hair follicle regeneration strategies using bulge cell-based approaches.

View this study on public-pages-files-2025.frontiersin.org →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis

research LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis

8 citations , June 2022 in “Scientific Reports”

LGR5 is a common marker of hair follicle stem cells in different animals and is important for hair growth and regeneration.

research Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine

4 citations , January 2022 in “Journal of Bioscience and Bioengineering”

Electric stimulation can increase hair growth by activating certain genes in skin cells.

research Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

1 citations , January 2020 in “Microscopy research”

Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.

research Hardwiring Stem Cell Communication Through Tissue Structure

82 citations , March 2016 in “Cell”

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

research Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling

22 citations , July 2015 in “PloS one”

Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.

research Stem Cell Heterogeneity and Plasticity in Epithelia

129 citations , May 2015 in “Cell Stem Cell”

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.