The Influence of CD26+ and CD26− Fibroblasts on the Regeneration of Human Dermo-Epidermal Skin Substitutes

    February 2022 in “ Scientific Reports ”
    Katarzyna Michalak‐Micka, Agnes S. Klar, Athanasia Dasargyri, Thomas Biedermann, Ernst Reichmann, Ueli Moehrlen
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    TLDR CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.
    The study investigated the role of CD26+ and CD26− fibroblasts in the regeneration of human dermo-epidermal skin substitutes using an in vivo model on immune-incompetent rats. It found that CD26+ fibroblasts were more active in producing extracellular matrix components, such as fibronectin and collagen, and facilitated faster ingrowth of blood capillaries, which are crucial for wound healing and tissue regeneration. CD26+ fibroblasts significantly enhanced epidermal stratification, dermal remodeling, and vascularization compared to CD26− fibroblasts. The study concluded that CD26+ fibroblasts play a crucial role in improving the structural and functional integration of skin substitutes, suggesting their potential in enhancing wound healing and tissue engineering applications.
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