The Transcription Factor CEBPB Is a Novel Hub Gene and Multi-Functional Disease Driver in Psoriatic Skin Inflammation

This study identified the transcription factor CEBPB as a novel hub gene and multi-functional disease driver in psoriatic skin inflammation. Researchers used a combination of transcriptomics and clinical phenotyping to find that CEBPB was significantly upregulated in the lesional skin of patients with Lichen Planus, Atopic Dermatitis, and Psoriasis, with the highest levels in Psoriasis. In vitro experiments showed that CEBPB knockout in Keratinocytes inhibited acanthosis development, cell proliferation, and mitochondrial metabolism, while reducing chemokine secretion. CEBPB levels correlated with clinical scores of acanthosis and neutrophil infiltration, suggesting its potential as a therapeutic target in skin inflammation.