The Effect of CgVEGF164 on the Growth of Murine Hair Follicles

The study investigated the effect of cgVEGF164, a variant of the cashmere goat VEGF-A gene, on murine hair follicles using transgenic mice. The research found that transgenic mice with the keratin 14 promoter-driven cgVEGF164 had significantly increased hair follicle diameter and density compared to non-transgenic controls. Additionally, these transgenic mice exhibited higher levels of protein phosphorylation for ERK1/2, AKT1, and LEF1, suggesting that cgVEGF164 enhanced hair follicle growth through these pathways. The study included five positive transgenic individuals, representing an 8.5% positive rate among neonatal mice.