Investigation of the Effect of Chitosan-Polycaprolactone Scaffolds Loaded with Chrysin-Capped Silver Nanoparticles in the Healing of Experimental Cutaneous Wound Defects in Rats

This study investigated the use of chitosan-polycaprolactone scaffolds loaded with chrysin-capped silver nanoparticles (AgNPs) for wound healing in rats. The AgNPs, synthesized using chrysin, demonstrated significant antibacterial activity against Staphylococcus aureus. In vivo experiments showed that wounds treated with these scaffolds had a wound closure rate of 85.7% compared to 69.4% in the control group after 7 days, indicating enhanced healing. The study concludes that these scaffolds effectively promote wound healing by reducing infection at the injury site.