Therapeutic Potential of Chitosan-Based and Related Nanocomposite Systems in Wound Management: A Review

The review explores the therapeutic potential of chitosan-based nanocomposite systems in wound management, particularly for chronic and diabetic wounds. These systems, enhanced by nanotechnology, improve drug delivery and wound healing outcomes by addressing challenges like poor solubility and stability. They offer regenerative, antioxidant, and antimicrobial properties that promote angiogenesis, fibroblast growth, and epithelial regeneration while reducing infection-related complications. Despite promising preclinical results, clinical application remains limited, and further research is needed to overcome translational barriers. The review emphasizes the synergistic effects of combining chitosan with polyphenols and metal-based nanoparticles, which enhance antimicrobial, anti-inflammatory, and regenerative properties, suggesting their potential as advanced wound therapy solutions.