Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells

July 1996 in “ Journal of Investigative Dermatology ”

Alain Limat, Davide Mauri, Thomas Hunziker

TLDR Using patient's own hair cells can effectively heal chronic leg ulcers.

The study discussed the successful treatment of chronic leg ulcers using epidermal equivalents generated from cultured autologous outer root sheath cells. This approach involved cultivating cells from the patient's own hair follicles to create skin grafts that were then applied to the ulcerated areas. The results indicated that this method was effective in promoting healing in chronic leg ulcers, suggesting a promising therapeutic avenue for patients with such conditions. The study highlighted the potential of using hair follicle-derived cells in regenerative medicine, particularly for skin repair.

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research Proliferation and Differentiation of Cultured Human Follicular Keratinocytes Are Not Influenced by Biotin

22 citations , January 1996 in “Archives of Dermatological Research”

research Formation of a Regular Neo-Epidermis by Cultured Human Outer Root Sheath Cells Grafted on Nude Mice

14 citations , April 1995 in “Transplantation”

Human hair follicle cells can be used to help heal and replace skin.

Effects of 1α,25-Dihydroxy-Vitamin D3 and Calcipotriol on Organotypic Cultures of Outer Root Sheath Cells: A Potential Model to Evaluate Antipsoriatic Drugs

research Effects of 1α,25-Dihydroxy-Vitamin D3 and Calcipotriol on Organotypic Cultures of Outer Root Sheath Cells: A Potential Model to Evaluate Antipsoriatic Drugs

10 citations , October 1993 in “Archives of dermatological research”

Vitamin D compounds may help treat psoriasis by promoting skin cell differentiation.

research Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells

62 citations , June 1993 in “Archives of Dermatological Research”

research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells

31 citations , December 1991 in “Annals of the New York Academy of Sciences”

ORS and hair matrix cells balance growth and differentiation better than normal keratinocytes, with human dermal fibroblasts crucial for proper differentiation.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research Growth of Human Hair Follicle Keratinocytes In Vitro

28 citations , November 1987 in “Journal of the American Academy of Dermatology”

The model successfully grew and differentiated hair follicle cells in the lab.

research A Method for Culturing Human Hair Follicle Cells

88 citations , January 1981 in “British Journal of Dermatology”

A new method helps grow human hair cells using a cow eye lens.