Cicatrizing Alopecias

    March 2017 in “ PubMed ”
    Salil K Pauja, A K Jaiswal
    TLDR Pseudopelade is likely an independent disease due to its distinct features.
    The study examined 30 cases of cicatricial alopecia, focusing on clinical features, histopathological findings, and hair examination. It identified distinct characteristics for different types of cicatricial alopecia: pseudopelade showed irregular atrophy with tufts of normal hair; folliculitis decalvans had inflammatory papules and pustules; DLE presented with cutaneous features; lichen planopilaris had violaceous atrophic patches; and morphoea showed sclerosed plaques. Histopathological analysis revealed specific patterns, such as elastic fiber accumulation in pseudopelade and irregular fibrosis in folliculitis decalvans. The study suggested pseudopelade as an autonomous disease due to its unique features.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  97 upvotes 9 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 2 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 1 year ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 9 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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