Cytochalasin B-Induced Adipose Stem Cell-Derived Nanovesicles Promote Hair Follicle Regeneration via Activation of the Beta-Catenin Signaling Pathway

The study investigates the effects of cytochalasin B-induced nanovesicles (CINVs) derived from adipose stem cells on hair follicle regeneration. CINVs were shown to enhance dermal papilla cell (DPC) proliferation, migration, and reduce apoptosis in vitro. In a mouse model, CINVs promoted the transition of hair follicles from the resting (telogen) phase to the growth (anagen) phase, evidenced by darkened skin and enlarged hair bulbs. These effects are primarily mediated through the activation of the β-catenin signaling pathway, as indicated by increased expression of β-catenin and related proteins. The study concludes that ADSC-derived CINVs effectively regulate DPC functions and promote hair follicle regeneration via β-catenin pathway activation.