Clascoterone: A New Topical Antiandrogen Agent

February 2025 in “ Prospects in Pharmaceutical Sciences ”

Magdalena Sitnik, Jakub Olszewski, M Bara, Piotr Armański, Katarzyna Herjan

clascoterone topical antiandrogen androgenetic alopecia dihydrotestosterone androgen receptors non-systemic treatment DHT

TLDR Clascoterone is a promising topical treatment for hair loss and acne with fewer side effects.

Clascoterone is a novel topical antiandrogen agent that has shown promise in the treatment of androgenetic alopecia and acne. The article discusses its mechanism of action, which involves blocking androgen receptors in the skin, thereby reducing the effects of dihydrotestosterone (DHT) that contribute to hair loss and acne. Clinical trials have demonstrated its efficacy and safety, with significant improvements observed in patients. The study highlights clascoterone's potential as a non-systemic treatment option, offering a favorable side effect profile compared to oral antiandrogens. This makes it a valuable addition to the therapeutic options for conditions driven by androgen activity.

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