Double Mutation of Claudin-1 and Claudin-3 Causes Alopecia in Infant Mice

March 2023 in “ Annals of the New York Academy of Sciences ”

Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita

claudin-1 claudin-3 alopecia hair follicles epithelial cell layers telogen phase hair retention epithelial proliferation hair loss hair growth hair regrowth

TLDR Mutations in claudin-1 and claudin-3 cause hair loss in baby mice.

The study investigates the role of claudin proteins in hair retention, focusing on CLDN1 and CLDN3. In mice with double mutations (Cldn1<sup>Δ/Δ</sup> Cldn3<sup>-/-</sup>), normal hair growth was observed initially, but significant hair loss occurred during the first telogen phase. This hair loss was linked to abnormalities in the hair follicles, such as disorganized epithelial cell layers and mislocalized bulges. These structural issues led to a shortened hair retention period and increased epithelial proliferation, resulting in accelerated hair regrowth in adult mice. The findings suggest that CLDN1 and CLDN3 are crucial for maintaining hair follicle architecture and preventing alopecia in infant mice.

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