4 citations
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January 2025 in “JAAD reviews.” Janus kinase inhibitors are promising for treating scarring alopecia, but more research is needed for safety and personalized treatments.
May 2024 in “JAMA Dermatology” Oral contraceptive use may increase the risk of frontal fibrosing alopecia in women with a specific CYP1B1 gene variant.
September 2023 in “Journal of Cosmetic Dermatology” Finasteride was more effective than hydroxychloroquine in treating frontal fibrosing alopecia.
16 citations
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August 2023 in “JAAD Case Reports” This document presents a case series involving 3 patients with refractory frontal fibrosing alopecia (FFA) treated with Janus kinase (JAK) inhibitors, specifically topical ruxolitinib and oral baricitinib. The study highlights significant clinical improvements, including reduced pruritus, perifollicular erythema, and scale, with some evidence of hair regrowth. The cases suggest that JAK inhibitors, particularly topical ruxolitinib, may be a promising treatment for FFA, potentially due to their ability to penetrate the thinner skin of the frontal scalp more effectively. The findings support the role of JAK1/JAK2 in the pathogenesis and treatment of FFA, although further research is needed to fully understand the mechanisms involved.
11 citations
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May 2023 in “Journal of Cutaneous Medicine and Surgery” Plasma Rich in Growth Factors may help reduce hair loss in Frontal Fibrosing Alopecia.
January 2023 in “Dermatologic Therapy” Intralesional corticosteroids and 5-alpha-reductase inhibitors are the best treatments for frontal fibrosing alopecia.
8 citations
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July 2020 in “Clinical, cosmetic and investigational dermatology” Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.
37 citations
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April 2019 in “Journal of The American Academy of Dermatology” Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.
14 citations
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April 2019 in “International Journal of Women's Health” Some treatments can stabilize Frontal Fibrosing Alopecia, but more research is needed to find effective treatments, and hair transplants often fail.
8 citations
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October 2018 in “Journal of The American Academy of Dermatology” The review suggests there's no agreed treatment for Frontal Fibrosing Alopecia, but hydroxychloroquine and 5a-reductase inhibitors are most effective. New treatments like platelet-rich plasma and LED light could help if standard treatments fail.
8 citations
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October 2016 in “Actas Dermo-Sifiliográficas” FFA in men, often mistaken for other hair loss types, may be more common than thought and needs larger studies for confirmation.
117 citations
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March 2013 in “Journal of the European Academy of Dermatology and Venereology” No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.
126 citations
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April 2006 in “International Journal of Dermatology” The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.
325 citations
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June 1994 in “Archives of Dermatology” Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.
