Clinical-Morphological Features and New Aspects of Keratoacanthoma Treatment: Narrative Review
June 2026
in “
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY
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TLDR Keratoacanthoma should be accurately diagnosed and treated based on its characteristics, often using surgery or tissue-preserving methods.
Keratoacanthoma (KA) is a well-differentiated epithelial tumor with rapid growth and low malignant potential, often resembling cutaneous squamous cell carcinoma (cSCC) both clinically and histopathologically. It typically appears as a dome-shaped nodule with a central keratin-filled depression and progresses through growth, stabilization, and spontaneous regression stages over 3–9 months. Accurate diagnosis requires histopathological examination due to its similarity to cSCC. Treatment should be tailored based on lesion characteristics and patient factors, with surgical excision preferred when malignancy is suspected. Tissue-preserving methods like intralesional methotrexate and cryotherapy may be suitable for selected patients. The review emphasizes the importance of dermoscopy in assessing lesions and planning individualized treatments.
