Collagen, Diet, And Lifestyle Disorders: Interactions Across Metabolic, Cardiovascular, Skin, Joint, And Gut Health

This review explores the role of collagen as a diet-responsive modulator in tissue repair, inflammation, and metabolic homeostasis, with a focus on its use in lifestyle-related disorders such as obesity, diabetes, and cardiovascular disease. Collagen supplements are popular for cosmetic benefits and musculoskeletal health, showing consistent, modest improvements in skin hydration and elasticity, and variable effects on body composition and cardiometabolic risk markers. However, the impact on glycemic endpoints is inconsistent. The review highlights the need for standardization in collagen source, molecular weight, dosing, and trial duration to improve generalizability. Future research should focus on product standardization, long-term safety, and mechanistic studies involving biomarkers and microbiome profiling.