Development and Evaluation of Crystalline Inclusion Complex of Finasteride Using Electrospraying as a Novel Approach

July 2020 in “ Journal of Drug Delivery Science and Technology ”

Kiran Katrajkar, Shreya Thakkar, Bhavesh Kshirsagar, Bhushan Sirsikar, Suryanarayana Polaka, Manju Misra

finasteride crystalline inclusion complex electrospraying in vitro release study Propecia

TLDR Created finasteride complex to increase water solubility and drug release.

The study developed a crystalline inclusion complex (CIC) of finasteride using electrospraying as a novel approach to improve its water solubility. The optimized parameters for preparing the CIC were an operating voltage of 18 kV, flow rate of 1.0 mL/h, and tip to collector distance of 15 cm. The CIC was characterized using various techniques, and the results showed that the process did not change the solid state of the drug. The in vitro release study showed a 1.6-fold increase in drug release compared to the unprocessed drug. The developed formulation was stable for 3 months at 25 °C.

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