CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signaling Pathway to Reduce Ferroptosis and Macrophage Polarization

This study investigates the effects of CuATSM on wound healing and scar formation using a full-thickness skin excision model in male ICR mice. The mice were divided into a Control group and a CuATSM group, with the latter receiving 30 mg/kg of CuATSM daily. The results show that CuATSM accelerates wound healing and reduces scar formation, particularly in the late healing phase. The underlying mechanism involves the ferroptosis-induced Hippo/YAP signalling pathway and macrophage polarisation. These findings suggest that CuATSM could be a promising therapeutic option for scarless wound repair in clinical settings.