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GlossaryFerroptosis

iron-dependent cell death caused by lipid peroxidation

Ferroptosis is a type of cell death that is distinct from other forms like apoptosis or necrosis. It is characterized by the accumulation of iron and the subsequent production of reactive oxygen species, leading to lipid peroxidation and cell membrane damage. This process is significant in various diseases, including cancer and neurodegeneration, and understanding it can help in developing targeted therapies.

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research Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

104 citations , June 2020 in “Journal of Endocrinology”

Hyperandrogenism and insulin resistance in PCOS-like rats can lead to pregnancy complications due to increased cell death in the uterus and placenta.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

N-acetylcysteine may help treat uterine and placental issues in PCOS.

research miR-761-hepcidin/Gpx4 pathway contribute to unexplained liver dysfunction in polycystic ovary syndrome by regulating liver iron overload and ferroptosis

16 citations , January 2023 in “Gynecological Endocrinology”

Liver damage in PCOS is linked to iron overload and cell death due to the miR-761-hepcidin/GPX4 pathway.

research Effect of Sun exposure-induced ferroptosis mechanisms on pathology and potential biological processes of primary melanoma by microarray data analysis

12 citations , September 2022 in “Frontiers in Genetics”

Enhancing CD8+ T cell function to induce ferroptosis in tumor cells may help treat skin melanoma.

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

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