Delta-6 Desaturase Knockout Mouse Illustrates Previously Undocumented Pathology

    April 2007 in “ The FASEB Journal ”
    Chad K. Stroud, Taka Y Nara, Wanda M. Haschek, B.H. Simon Cho, Manabu Nakamura
    TLDR Lack of certain fatty acids causes skin, immune, and fertility issues in mice.
    The study involving Delta-6 desaturase (D6D) knockout mice revealed previously undocumented pathologies associated with the deficiency of arachidonic acid (AA) and docosahexaenoic acid (DHA). The D6D knockout mice, which were unable to convert linoleic acid (LA) to AA and linolenic acid (LNA) to DHA, developed hair loss and ulcerative dermatitis despite having LA in their diet. Additionally, these mice exhibited decreased thymic weight due to a lack of cortical T-cells, enlarged spleens due to increased hematopoiesis and myelopoiesis, and reduced lymphoid tissue. The ovaries of the knockout mice lacked corpora lutea, potentially explaining their reduced fertility. These findings highlighted the critical roles of AA and DHA in maintaining skin integrity, regulating estrus cycles, and developing immune cells.
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