Relation Between Dermal Papilla Cells and Androgenetic Alopecia

The document reviewed the relationship between dermal papilla cells and androgenetic alopecia, the most common type of hair loss, known to be a polygenic hereditary disease influenced by androgen levels, particularly dihydrotestosterone, and psychological factors. Dermal papilla cells, derived from fibroblasts, are mesenchymal cells that form the dermal papilla, express androgen receptors, secrete various cytokines, and induce hair follicle regeneration, playing a crucial role in regulating the cyclical growth of hair follicles. These cells are involved in androgen metabolism, and androgens induce susceptible hair follicle dermal papilla cells to secrete cytokines, leading to hair loss, indicating a close relationship between dermal papilla cells and androgenetic alopecia.