Dermoelectroporation-Enhanced Delivery of Human Placental Mesenchymal Stem Cell-Derived Exosomes for Regenerative Applications: A Systematic Review and Meta-Analysis

    December 2025 in “ Journal of Surgery
    Greg Chernoff, Jenna Himmelstein
    TLDR This technique improves delivery and effectiveness of exosomes for tissue regeneration.
    This systematic review and meta-analysis evaluates the effectiveness of dermoelectroporation-enhanced delivery of human placental mesenchymal stem cell-derived exosomes for regenerative applications. The study synthesizes data from multiple trials to assess the potential benefits of this delivery method in promoting tissue regeneration. The findings suggest that this technique significantly enhances the delivery and efficacy of exosomes, leading to improved regenerative outcomes. The analysis includes a comprehensive review of existing literature, highlighting the promising role of this advanced delivery system in regenerative medicine. However, further research with larger sample sizes is recommended to validate these findings and optimize treatment protocols.
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