A Natural Deep Eutectic Solvent Formulation Promotes Hair Growth by Enhancing the Transdermal Delivery and Bioactivity of Hydroxytyrosol

    January 2026 in “ Journal of Materials Chemistry B
    Y. G. Xie, Kan Zeng, Puying Yang, Ting Zheng, Xinlei Zhao, Zhiai Hu, Fan Li, He Song, L YE, Ding Xiong, Zi Wang, Y.J. Shi
    TLDR A special solvent helps hydroxytyrosol penetrate skin better, promoting hair growth.
    The study investigates a novel deep eutectic solvent (DES) formulation to enhance the transdermal delivery and bioactivity of hydroxytyrosol (HT), a compound with antioxidant properties, for promoting hair growth. The DES system, composed of betaine, urea, and lactic acid (BUL), significantly improves the skin penetration of HT, achieving over threefold greater permeation compared to aqueous solutions. In vivo studies demonstrated that HT@BUL effectively promotes hair regrowth and is highly biocompatible. Additionally, in vitro assays showed that HT-loaded BUL has ROS-scavenging activity, stimulates cell proliferation, and reduces cellular senescence. This research suggests that combining antioxidant molecules with BUL could be a promising therapeutic approach for hair regrowth.
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