Development of Novel Drug Delivery Systems for the Treatment of Alopecia

This review explores novel drug delivery systems (NDDS) for alopecia treatment, focusing on enhancing drug localization in the pilosebaceous unit to improve follicular retention and reduce systemic exposure and irritation. It discusses various delivery systems, including lipid-based carriers, polymeric nanoparticles, and vesicular systems, which show promise for improved follicular targeting and sustained release. The review emphasizes the potential of combining these systems with biologic therapies like exosomes for enhanced hair regeneration. However, it highlights the need for rigorous safety assessments, manufacturing standardization, and clinical evidence to ensure efficacy and patient compliance, as no single delivery system is universally optimal.