Metabolism of Dehydroepiandrosterone by Isolated Human Hair Follicles

December 1971 in “ European Journal of Endocrinology ”

Á Fazekas

dehydroepiandrosterone DHEA testosterone androstenedione dihydrotestosterone DHT steroid hormones hair follicles enzymatic capability

TLDR Human hair follicles can process steroid hormones like DHEA.

The document reported that isolated human hair follicles were capable of metabolizing dehydroepiandrosterone (DHEA). It was found that these follicles could convert testosterone into androstenedione and dihydrotestosterone. This finding suggested that hair follicles had the enzymatic capability to process steroid hormones, which could have implications for understanding hair growth and hair loss mechanisms.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 140 upvotes 10 months ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community Please take a vitamin & hormone test

in Chat 259 upvotes 1 year ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 10 months ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

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