Dihydrotestosterone, and Not Testosterone, Enhances the LPS-Induced Inflammatory Cytokine Gene Expression in Human Adipocytes

    April 2023 in “ Biomedicines ”
    Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
    TLDR Dihydrotestosterone boosts inflammation in fat cells more than testosterone.
    The study demonstrates that dihydrotestosterone (DHT), rather than testosterone, significantly enhances lipopolysaccharide (LPS)-induced inflammatory cytokine gene expression in human adipocytes. This finding highlights the role of sex hormones in adipose tissue inflammation, specifically identifying non-aromatizable androgens like DHT as key amplifiers of the inflammatory response.
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