Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm

    January 2020 in “ The World Journal of Men's Health ”
    Abdulmaged M. Traish
    TLDR Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.
    The document highlighted significant health risks associated with long-term use of finasteride and dutasteride, commonly prescribed for benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA). These drugs induced a novel form of androgen deficiency, leading to various metabolic dysfunctions such as non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR), type 2 diabetes mellitus (T2DM), dry eye disease, and potential kidney dysfunction. Studies in both animal models and human subjects indicated liver lipid accumulation, impaired glucose disposal, and increased risk of T2DM. A cohort study of 230 men treated with dutasteride for 36-42 months showed increased blood glucose, cholesterol levels, and liver enzyme activities. The review called for heightened awareness of these potential adverse effects and reconsideration of prolonged use of these medications.
    Discuss this study in the Community →

    Research cited in this study

    25 / 25 results

    Related Community Posts Join

    6 / 1000+ results

      community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

      in Research/Science  10 upvotes 1 year ago
      Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  109 upvotes 1 week ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 1 year ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

      community Testosterone and Estradiol levels on 1 mg/day dutasteride

      in Finasteride/Dutasteride  43 upvotes 4 months ago
      A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.

    Related Research

    6 / 6 results