Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis

This study assessed the effectiveness and safety of diphenylcyclopropenone (DPCP) in 18 patients with Alopecia Totalis and Alopecia Universalis. After 6 months, 33.3% of patients had more than 75% hair regrowth, and 61.1% showed partial regrowth. A "castling phenomenon" was observed, with 63.6% of AU patients experiencing body hair regrowth. Side effects were common but manageable, affecting 55.5% of patients. The study concluded that DPCP is a promising treatment for AT/AU, although the small sample size limits its broader applicability.