Treatment of Discoid Lupus Erythematosus Scarring Alopecia with Deucravacitinib: A Case Report

January 2025 in “ SAGE Open Medical Case Reports ”

Katherine Aw, Geneviève Gavigan

discoid lupus erythematosus scarring alopecia deucravacitinib tyrosine kinase 2 inhibitor

TLDR Deucravacitinib helped regrow hair and reduce plaques in a woman with discoid lupus erythematosus without side effects.

A 48-year-old woman with treatment-refractory discoid lupus erythematosus, characterized by scarring scalp plaques and alopecia, was treated with deucravacitinib, a tyrosine kinase 2 inhibitor. After 3 months, she experienced symptom resolution and 1-2 cm of hair regrowth, with further significant hair regrowth and plaque reduction observed at 6 months. The treatment was well-tolerated with no side effects, suggesting deucravacitinib as a promising therapy for refractory cases of this condition.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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community This is what Six years of DUT looks like

in Finasteride/Dutasteride 791 upvotes 3 years ago

User had success with dutasteride for hair loss after finasteride didn't work. Some experienced increased cholesterol and debated its relation to DHT.

community I am waiting for cosmerna to come out but I don’t know how could I possibly apply 1ml on my whole scalp. I am mostly receding but i am also diffuse thinning everywhere and I think started losing my crown going into Norwood 4 basically

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community Kintor KX-826 Group Buy Feedback

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The conversation is about a group of people trying KX-826 for hair loss, with no serious side effects reported after 25 days of use. Some participants are experiencing less scalp itch and shedding, but it's too early for definitive results.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

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Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

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