Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Bojie Lin, Jiangying Zhu, Guo-Qian Yin, Mingde Liao, Guanyu Lin, Yuyong Yan, Dan Huang, Siding Lu
    TLDR DLX5 helps hair follicle stem cells differentiate by activating a specific pathway.
    The study explored the role of the transcription factor DLX5 in hair follicle stem cell (HFSC) differentiation, revealing that DLX5 promoted differentiation by regulating the c-MYC/microRNA-29c-3p/NSD1 axis. DLX5 increased c-MYC expression, which suppressed miR-29c-3p, allowing NSD1 to facilitate differentiation. The research utilized in vitro experiments with HFSCs from Sprague-Dawley rats and various molecular biology techniques to validate these findings. The study provided insights into the molecular mechanisms of HFSC differentiation and suggested potential therapeutic targets for hair growth and regeneration.
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