Dedicator Of Cytokinesis 5 Regulates Keratinocyte Function And Promotes Diabetic Wound Healing

    February 2021 in “ Diabetes ”
    Hua Qu, Miao Tian, Yuren Wang, Liang Tan, Bangliang Huang, Linlin Zhang, Xiufei Liu, Min Long, Rui Zhang, Xiaoyu Liao, Xiaoli Gong, Wang Ju, Xin Xiong, Junli Liu, Xi Li, Yu Jiang, Gangyi Yang, Zhiming Zhu, Hongting Zheng, Yi Zheng
    TLDR Dock5 is important for skin healing and could help treat diabetic wounds.
    The study investigated the role of Dedicator of Cytokinesis 5 (DOCK5) in keratinocyte function and diabetic wound healing, involving six diabetic foot ulcer patients and six healthy participants, along with mouse models. DOCK5 was found to be crucial for keratinocyte migration, proliferation, and adhesion, which are essential for wound healing. In diabetic conditions, DOCK5 expression was reduced, leading to impaired healing. However, restoring DOCK5 expression improved wound healing by enhancing extracellular matrix remodeling and keratinocyte function. The study suggested that targeting DOCK5 could be a potential therapeutic strategy for improving wound healing in diabetic patients.
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