TLDR Blocking CXXC5 speeds up diabetic wound healing by improving blood vessel growth and skin repair.
The study investigates the role of CXXC-type zinc finger protein 5 (CXXC5) in diabetic wound healing, particularly in diabetic foot ulcers (DFUs). CXXC5 is identified as a negative regulator of the Wnt/β-catenin pathway, which is crucial for wound healing and angiogenesis. The research found that CXXC5 is overexpressed in DFU patients and diabetes-induced model mice, leading to suppression of the Wnt/β-catenin pathway. The study introduces KY19334, a small molecule that inhibits the CXXC5-Dvl interaction, thereby activating the Wnt/β-catenin pathway. This activation accelerates wound healing in diabetic mice and induces angiogenesis in hindlimb ischemia model mice. The findings suggest that targeting CXXC5 to restore Wnt/β-catenin signaling could be a promising therapeutic strategy for DFUs.
13 citations
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March 2021 in “British Journal of Pharmacology” KY19382 helps regrow hair and create new hair follicles.
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November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
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June 2017 in “Journal of Investigative Dermatology” Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.
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July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
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October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
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January 2022 in “Signal Transduction and Targeted Therapy” The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
24 citations
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August 2021 in “Scientific Reports” Non-thermal plasma could help hair growth by activating key cell signals.
February 2024 in “Frontiers in physiology” Modifying certain signals in the body can help wounds heal without scars and regrow hair.
