Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics

The review explores the dual regenerative and antimicrobial properties of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC), which are used in tissue repair and regeneration. These biologics offer benefits through growth factors and cellular components that promote healing and reduce infection risk. PRP is effective in treating musculoskeletal conditions, wound healing, and hair follicle regeneration, with low adverse event rates (1-3%) and antimicrobial properties. BMAC, rich in mesenchymal stem cells, promotes tissue regeneration and has antibacterial activity. However, challenges such as inconsistent preparation methods, lack of standardization, and limited long-term safety data affect their clinical outcomes. The review emphasizes the need for standardized procedures and robust research to optimize the clinical integration of these therapies in pain medicine.