Supplementary Material for: Case Report - Hair Shaft Normalization and Hair Growth in SPINK5-Syndromic Epidermal Differentiation Disorder (Netherton Syndrome) While on Treatment with Dupilumab: A Novel Therapeutic Approach for Trichorrhexis Invaginata

This case report discusses a 67-year-old woman with Netherton syndrome (NS), a genetic disorder characterized by skin inflammation and hair defects, specifically Trichorrhexis invaginata (TI). The patient was treated with dupilumab, a biologic known for addressing cutaneous inflammation. After 3 months, the patient experienced significant improvements in skin rash, pruritus, and quality of life. Notably, the treatment led to the normalization of hair shafts and promoted hair growth, resolving the "bamboo" hair characteristic of TI. This case highlights dupilumab's potential in addressing hair abnormalities associated with NS, an area not extensively covered in current literature.