Search

for
Search:

GlossaryNetherton Syndrome

rare genetic disorder causing skin inflammation and brittle hair

Netherton Syndrome is a rare genetic disorder characterized by chronic skin inflammation, a distinctive hair shaft abnormality called trichorrhexis invaginata (bamboo hair), and a predisposition to allergies and infections. It is caused by mutations in the SPINK5 gene, which affects the skin's barrier function, leading to symptoms like red, scaly skin and brittle hair.

Related Terms

Learn

5 / 801 results

learn phenylanine

learn unspecified lectican proteoglycans (nourkrin)

learn Ensete ventricosum

learn nettle

learn nicotinamide

View more "netherton syndrome" in learn →

Research

5 / 308 results

research KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

87 citations , January 2017 in “PLoS Genetics”

Removing both KLK5 and KLK7 proteins can prevent death and skin issues in Netherton syndrome.

research Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome

42 citations , January 2007 in “Pediatric dermatology”

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

research Hair Shaft Videodermoscopy in Netherton Syndrome

41 citations , December 2008 in “Pediatric Dermatology”

Trichoscopy can diagnose Netherton syndrome without pulling hairs.

research Trichoscopy as a diagnostic tool in trichorrhexis invaginata and Netherton syndrome

30 citations , February 2015 in “Anais Brasileiros de Dermatologia”

Trichoscopy is useful for diagnosing Netherton syndrome in children with skin issues.

research Netherton Syndrome Associated with Growth Hormone Deficiency

21 citations , September 2013 in “Pediatric Dermatology”

Growth hormone therapy can improve growth in Netherton syndrome patients with growth hormone deficiency.

View more "netherton syndrome" in research →

Community Join

5 / 1000+ results

community norwood 7 from both sides of family, destined to go bald 17M

in Chat 9 upvotes 2 years ago

17M approaching Norwood 2, using topical minoxidil and considering finasteride, oral minoxidil, and pyrilutamide. Plans to study dermatology and possibly get a hair transplant at 25 if treatments don't work.

community Assembling a list of exceptional Norwood 6/7 cases, open for your contributions.

in Progress Pictures 44 upvotes 2 years ago

The conversation is about people with advanced hair loss (Norwood 6 or 7) who have seen significant hair regrowth using treatments like finasteride, minoxidil, microneedling, and RU58841. Nine cases were collected to motivate others to try these treatments despite advanced hair loss.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Anagenic is trying to compound Gt20029

in Treatment 55 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

View more "netherton syndrome" in community →