Development of Dutasteride Loaded Dissolving Microneedles for Transdermal Permeation

The study developed dissolving microneedles (DMNs) loaded with dutasteride to enhance transdermal delivery for treating androgenic alopecia (AGA). Using a polymer matrix, the DMNs improved the solubility of dutasteride, which is typically poorly soluble. In vitro studies demonstrated efficient drug release and significant accumulation in hair follicles, indicating the potential of DMNs as an advanced treatment option for AGA. The research highlights the innovative use of DMN technology in transdermal drug delivery, suggesting its applicability for various therapeutic areas requiring targeted, painless, and efficient delivery.