Supplementary Material For: Effects Of Food-Derived Collagen Peptides On The Expression Of Keratin And Keratin-Associated Protein Genes In The Mouse Skin

January 2017

Phuong Vu, R. Takatori, T. Iwamoto, Y Akagi, Hideo Satsu, Mamoru Totsuka, Kazuhiro Chida, Kazuhiro Sato, Makiko Shimizu

collagen peptides prolyl-hydroxyproline keratin keratin-associated protein Krtap genes Krt genes keratinocytes fibroblasts epidermis development hair cycle collagen Pro-Hyp

TLDR Collagen peptides may boost skin and hair-related gene expression.

The study investigated the effects of oral collagen peptides (CP) on gene expression in hairless mouse skin and the impact of the collagen-derived dipeptide prolyl-hydroxyproline (Pro-Hyp) on gene expression in a coculture of mouse skin keratinocytes and fibroblasts. After 6 weeks of CP administration, there was an increased expression of Krtap and Krt genes, which are associated with epidermis development and the hair cycle. Pro-Hyp also increased the expression of several Krtap genes in keratinocytes, but only in the presence of fibroblasts, indicating their essential role. This research provided new insights into how CP might influence the skin and hair cycle.

View this study on karger.figshare.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 687 results

community Please listen. If you want to save your hair.

in Progress Pictures 126 upvotes 3 years ago

User discusses two medications for stopping hair loss: Fin (finasteride) and Dut (dutasteride). Mixed experiences and side effects are shared, with some users seeing positive results.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 3 years ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community Collagen peptides(powder) i highly recommend

in Product 8 upvotes 8 months ago

Collagen peptides are recommended for hair and skin benefits, with users noting improvements in hair and skin health. However, evidence on their effectiveness for hair growth is inconclusive.

community Can i take Glycine 1000 mg and Collagen peptides together, or will it increase DHT?

in Chat 1 upvotes 1 year ago

A user on Finasteride for over a year is asking if taking Glycine 1000 mg at night along with morning collagen peptides will increase DHT and cause hair loss. They are concerned about the potential impact on their hair loss treatment.

community I believe the key for most NW2 to NW3 with no alopecia but more of receding hairline is caused by lack of blood flow and collagen in front of scalp. How do you rebuild collagen? What supplements to add when dermarolling?

in Treatment 3 years ago

Minoxidil helped with hairline regrowth, but stopping it led to hair loss, suggesting circulation issues. Dermarolling, collagen peptides, and oils like castor and rosemary are recommended for improving hair health.

community Minxodil collegen synthesis decrease?

in Minoxidil 3 upvotes 1 year ago

Minoxidil may age skin by slowing collagen synthesis, but using collagen peptides and a basic skincare routine might counteract this. Foam minoxidil could reduce systemic absorption and avoid alcohol-related side effects.

Related Research

1 / 1 results

research Keratin Intermediate Filaments in the Colon: Guardians of Epithelial Homeostasis

38 citations , November 2020 in “International journal of biochemistry & cell biology”

Keratin proteins are essential for keeping the cells in the human colon healthy and stable.