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GlossaryHair Cycle Clock

internal mechanism regulating hair growth, rest, and shedding phases

The Hair Cycle Clock refers to the internal biological mechanism that regulates the phases of hair growth, rest, and shedding. This cycle includes the anagen (growth), catagen (transitional), and telogen (resting) phases, ensuring that hair follicles undergo a synchronized process of renewal and shedding. Understanding this clock is crucial for diagnosing and treating hair disorders like alopecia.

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Research

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research Lgr5 marks cycling, yet long-lived, hair follicle stem cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research The hair cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

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Community Join

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community if hair follicle miniaturization happens slowly and gradually over a few hair cycles then wouldn't that mean that to regain maximum or top thickness from treatment you would at least need 5-10 years?

in Research/Science 53 upvotes 8 months ago

Hair regrowth from treatments like finasteride, dutasteride, and minoxidil can take several years, with most visible results appearing within 1-2 years and potential improvements continuing up to 10 years. Consistency and patience are crucial for achieving maximum hair thickness, as hair miniaturization and regrowth are gradual processes.

community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 2 years ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community Cycle of Hair Loss: Fin to Dut Transition without Improvement

in Basic Questions 129 upvotes 3 months ago

The user has been experiencing worsening hair loss despite using finasteride, minoxidil, and later switching to dutasteride. Despite normal bloodwork and consulting dermatologists, the hair loss continues without improvement.

community True hair loss Vs shedding cycle

in Finasteride/Dutasteride 2 upvotes 6 months ago

The user stabilized hair loss with oral finasteride, dutasteride, and topical minoxidil, and underwent a stem cell and PRP procedure. Recent increased hair shedding may be due to restarting dermarolling, affecting minoxidil absorption, or the waning effects of the stem cell treatment.

community Stemoxydin and hair cycle question

in Treatment 2 upvotes 2 years ago

The user has been using Finasteride for hair loss and is considering adding alphatradiol, stemoxydine, or 2% minoxidil to their regimen. They are concerned that stemoxydine, which shortens the resting phase of hair, might accelerate hair loss in those not using Finasteride by depleting hair cycles without strengthening miniaturized hairs.

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