TLDR Finasteride safely lowers DHT levels without affecting testosterone.
Finasteride is a drug that inhibits 5α-reductase and reduces DHT levels in male volunteers. It does not affect testosterone and androstenedione levels. It is a potential treatment for androgen-dependent conditions like benign prostatic hyperplasia and male pattern baldness. The study found that finasteride is a safe and effective inhibitor of 5α-reductase in men, leading to a significant decrease in serum DHT levels. No adverse effects were reported during the study.
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November 1988 in “The Journal of Clinical Endocrinology & Metabolism” Higher levels of a specific hormone are linked to more chest hair and acne in men.
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October 1987 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Measuring androstanediol glucuronide in blood is useful for assessing and tracking treatment in women with excessive hair growth.
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May 2019 in “International Journal of Environmental Research and Public Health” Finasteride may cause kidney damage.
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April 1995 in “Journal of Medicinal Chemistry” The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
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July 2022 in “Clinical Cosmetic and Investigational Dermatology” Clascoterone 1% cream is a promising new treatment for acne.
July 2023 in “Journal of Drug Delivery Science and Technology” Finasteride niosomes were developed and found to be effective in treating hair loss, with better results than commercial minoxidil, and could be a promising topical treatment for hair loss.
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