Comparative Efficacy and Safety of Platelet-Rich Plasma, Injectable Platelet-Rich Fibrin, and Concentrated Growth Factors for Female Pattern Hair Loss: A Prospective Multicenter Randomized Clinical Trial

In a study of 74 women with female pattern hair loss, the efficacy and safety of platelet-rich plasma (PRP), injectable platelet-rich fibrin (i-PRF), and concentrated growth factors (CGF) were compared over 24 weeks. CGF and i-PRF significantly outperformed PRP in increasing non-vellus target area hair count (TAHC), with increases of 27.11% and 26.54% respectively, compared to 14.53% for PRP. Hair diameter improvements were similar across all groups, and the i-PRF group had the fewest adverse events. Vascular endothelial growth factor (VEGF) levels correlated positively with TAHC increases, suggesting a role in hair growth. The study concludes that CGF and i-PRF are more effective and safe than PRP for treating female pattern hair loss.