Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

May 2018 in “ Dermatologic Surgery ”

Amelia K. Hausauer, Derek K. Jones

platelet-rich plasma androgenetic alopecia PRP AGA

TLDR PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

This document is a compilation of summaries of different studies that evaluated the efficacy of platelet-rich plasma (PRP) regimens for managing androgenetic alopecia (AGA) in single-center, blinded, randomized clinical trials. The studies found that PRP injections are an effective and well-tolerated therapy for AGA, with both monthly treatments transitioning to every three months and two sessions every three months showing positive results. The injection technique used was safe and well-tolerated, and both men and women responded similarly. However, further research is needed to determine the optimal PRP regimen.

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research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , September 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , September 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

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58 citations , January 2015 in “International Journal of Trichology”

Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.

research Platelet-Rich Plasma for Androgenetic Alopecia

107 citations , August 2014 in “Dermatologic Surgery”

PRP injections improve hair thickness for baldness.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , December 2012 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

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207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

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166 citations , August 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

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152 citations , October 2010 in “Archives of Dermatology”

Finasteride helps hair growth but may cause sexual side effects.

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34 citations , April 2009 in “Expert Opinion on Pharmacotherapy”

Some treatments work for common baldness, but there's less evidence for other hair loss types, and more research is needed.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

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215 citations , November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

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251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

Evaluation of Androgens in the Scalp Hair and Plasma of Patients with Male-Pattern Baldness Before and After Finasteride Administration

research Evaluation of Androgens in the Scalp Hair and Plasma of Patients with Male-Pattern Baldness Before and After Finasteride Administration

25 citations , January 2006 in “British Journal of Dermatology”

Finasteride lowers scalp and blood DHT levels, potentially treating male-pattern baldness.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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269 citations , August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

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77 citations , April 1999 in “Dermatologic Clinics”

The document concludes that follicular unit transplantation offers more natural results and better graft survival than older hair transplant methods.

Finasteride in the Treatment of Men with Androgenetic Alopecia