Epithelial–Mesenchymal Transition in Cutaneous Fibrosis Disease: From Mechanisms to Therapy

June 2026 in “ Frontiers in Immunology ”

Shaoxiang Yuan, Ziyi Luo, Nina Yang, Tao Xiong, Yunpeng Chen, Xichao Jian, Yun Wang, Shune Xiao, Junzhe Chen, Chengliang Deng

cutaneous fibrosis epithelial–mesenchymal transition chronic inflammation fibrogenesis autoimmune reactions

TLDR EMT plays a key role in skin fibrosis and offers new therapy targets.

Cutaneous fibrosis is characterized by abnormal tissue remodeling due to chronic inflammation, tissue trauma, or autoimmune reactions, leading to decreased tissue function and reduced quality of life. The epithelial–mesenchymal transition (EMT) is identified as a critical factor in the development of fibrotic disorders, although its exact contribution compared to other cell sources is not fully understood. Recent findings highlight EMT's role in fibrogenesis and suggest new molecular targets for therapy. This review aims to enhance understanding of EMT's regulatory mechanisms in cutaneous fibrosis and explore potential treatment strategies.

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