Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

This review discussed the roles of epithelial-mesenchymal plasticity (EMP) and endothelial-to-mesenchymal transition (EndMT) in cutaneous wound healing. It highlighted the reversible nature of EMP, where epithelial cells transition across multiple states, and emphasized the importance of restricting epithelial-to-mesenchymal transition (EMT) for effective wound reepithelialization. The review also explored the potential contribution of EndMT to wound fibrosis and scar formation. By understanding these processes, new therapeutic opportunities could be developed to address human wound healing pathologies.