Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes via the Gut Microbiota–Intestinal Barrier Axis in Aged Mice

May 2026 in “ Nutrients ”

Y Naito, Katsura Mizushima, Ryo Inoue, Tomohisa Takagi

This study demonstrates that enhancing quercetin bioavailability using EubioQuercetin (EQN) significantly reduces aging phenotypes in aged mice, as evidenced by a lower aging score compared to controls. EQN treatment led to beneficial changes in gut microbiota composition, suppressing taxa associated with aging and promoting those linked to a healthier profile. Additionally, EQN modulated intestinal gene expression by downregulating senescence-associated genes and upregulating the tight junction gene claudin-1. These results suggest that the gut microbiota–intestinal barrier axis plays a crucial role in the anti-aging effects of quercetin.

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