Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes Via the Gut Microbiota–Intestinal Barrier Axis in Aged Mice

This study examined the impact of EubioQuercetin (EQN), a highly bioavailable form of quercetin, on aging phenotypes in aged male C57BL/6J mice. Over 12 weeks, EQN significantly reduced aging scores related to hair glossiness, hair loss, and white hair presence compared to conventional quercetin. The study involved 28 mice and found that EQN improved gut microbiota composition by increasing beneficial bacteria and reducing aging-associated taxa, while also enhancing intestinal barrier function. These results suggest that enhancing quercetin bioavailability through EQN can modulate the gut microbiota–intestinal barrier axis, offering a promising strategy for promoting healthy aging. However, the study's limitations include its reliance on a single animal model, indicating a need for further research in humans.