Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata

    January 2024 in “ BioMed Research International ”
    Giovanni Damiani, Laura Cristina Gironi, Rosalynn R.Z. Conic, Massimo Del Fabbro, Paola Savoia, Marco Fiore, Wilma F. Bergfeld
    TLDR Patients with alopecia areata and eosinophilia have more nail issues and severe hair loss.
    This study investigated the relationship between alopecia areata (AA) and eosinophilia in a sample of 205 patients, finding that 18.5% had concurrent eosinophilia. These patients exhibited a higher prevalence of atopia and nail abnormalities compared to those without eosinophilia, and they had 3.70 times higher odds of experiencing more severe hair loss. The findings suggest that AA patients with eosinophilia have distinct clinical characteristics, indicating that future research could explore the potential use of IL-5 inhibitors for treatment.
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