Estimation Methods for Human Circadian Phase Using Peripheral Tissues

    June 2016 in “ Hypertension research ”
    Ritsuko Matsumura, Koichi Node, Makoto Akashi
    Image of study
    TLDR New method uses hair follicle cells to estimate human body clock phase, potentially improving sleep disorder diagnosis.
    The document from June 23, 2016, presents a novel method for estimating human circadian phases using clock gene expression in hair follicle cells, which could aid in diagnosing circadian rhythm sleep disorders. This method is seen as more convenient and objective compared to traditional melatonin level assessments like DLMO. It involves collecting hair follicle cells and using real-time PCR to measure the expression levels of genes such as Per3, Nr1d1, and Nr1d2. By fitting a cosine curve to the gene expression levels at various times, the peak times of these genes can be determined, revealing potential circadian misalignment with an individual's lifestyle. The authors highlight the increased prevalence of circadian maladjustment due to modern lifestyle habits, such as the use of light-emitting devices at night, and suggest that their method could improve the diagnosis and treatment of sleep disorders by providing an objective assessment of circadian phase to guide therapy timing. However, they acknowledge that further research is needed to confirm the accuracy of this method in reflecting the central circadian phase and to address potential race-based differences in sample collection.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  109 upvotes 1 week ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

      in Progress Pictures  492 upvotes 3 years ago
      A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

      community My Theory Of Androgenic Alopecia

      in Research/Science  21 upvotes 2 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community Regrowth with only Nizoral and Lifestyle Changes; focusing on scalp health & nervous system

      in Is this regrowth?  86 upvotes 2 weeks ago
      The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.

    Similar Research

    5 / 1000+ results