Extracellular Vesicle-Derived lncRNA VIM-AS1 Promotes Diabetic Wound Healing by Promoting Glycolysis and Alleviating Cellular Senescence

    July 2025 in “ Stem Cell Research & Therapy ”
    Feiyuan Liang, Nanchang Huang, Yu Tian, Yuqi Fang, Chuangming Huang, Boyuan Qiu, Tiantian Lu, Zheng Li, Jianwen Cheng, Bo Zhu, Jinmin Zhao
    TLDR lncRNA VIM-AS1 helps heal diabetic wounds by boosting energy production and reducing cell aging.
    The study investigates the role of extracellular vesicle-derived lncRNA VIM-AS1 from human mesenchymal stem cells (HuMSCs) in promoting diabetic wound healing. It demonstrates that lncRNA VIM-AS1 enhances glycolysis and reduces cellular senescence, which are critical processes in tissue repair. The findings suggest that HuMSCs-derived EVs and lncRNA VIM-AS1 could be promising therapeutic strategies for improving wound healing in diabetic patients.
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