Exosome-Based Therapies: Protocol Development for Androgenetic Alopecia

Exosome-based therapies present a promising noninvasive approach for treating androgenetic alopecia (AGA) by leveraging mesenchymal stem cell-derived exosomes to enhance follicular regeneration through paracrine signaling. Despite encouraging early results, widespread clinical adoption is hindered by the lack of standardized protocols, variability in donor sources, and incomplete understanding of mechanisms. A clinical case demonstrated significant improvement in hair density using exosome therapy, but broader clinical relevance requires consistent methodology and robust research. Advancing exosome therapy from experimental to mainstream use will necessitate rigorous standardization, multicenter trials, and transparent quality control to ensure efficacy and safety.