Advancing Human Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes for Androgenetic Alopecia: Appraisal and Methodological Recommendations

December 2025 in “ World Journal of Stem Cells ”

Yu Jiang, Wen-Jun Huang, Rui Zhou

human adipose-derived mesenchymal stem cell exosomes androgenetic alopecia CDC42 Wnt/β-catenin signaling glycogen synthase kinase 3β microneedle delivery

TLDR Exosome-based therapies could help treat hair loss, but more research is needed.

Fu et al explored the use of human adipose-derived mesenchymal stem cell exosomes for treating androgenetic alopecia, identifying 232 stable proteins and suggesting the CDC42-Wnt/β-catenin-glycogen synthase kinase 3β signaling axis as a potential therapeutic pathway. They recommend further research to enhance clinical relevance, including comprehensive exosome characterization, dose-response relationship establishment, direct validation of CDC42’s role, multi-level evaluation of Wnt/β-catenin signaling, biochemical validation in animal models, quantitative analysis of microneedle delivery, and development of quality control and safety frameworks. These steps aim to align exosome-based therapies with regulatory standards and improve their clinical application.

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Research cited in this study

3 / 3 results

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