Exosomes in Trichology: A Literature Review

November 2025 in “ JPRAS Open ”

Kar Wai Alvin Lee, Olena Sydorchuk, Jong Keun Song, S. Lee, Eugene Yu, S. Kim, Tae Hyun Kim, Han Ah Reum Song, Se-Hoon Shim, You-kyoung Cho, Helen Seunghye Lee, Arash Jalali, Kyu‐Ho Yi

exosome therapy androgenetic alopecia alopecia areata chemotherapy-induced alopecia GMP-compliant production AGA AA CIA

Exosome therapy shows promise as a minimally invasive treatment for androgenetic alopecia (AGA), alopecia areata (AA), and chemotherapy-induced alopecia (CIA), with strong support from preclinical studies. However, clinical data are still preliminary and varied. To advance exosome therapy into routine clinical practice, there is a need for large-scale, multicenter randomized trials with standardized outcomes. Additionally, harmonized manufacturing and regulatory frameworks, including GMP-compliant production and batch-level quality control, are essential to ensure the reproducibility and safety of this therapy.

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Research cited in this study

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Successful Treatment of Hair Loss and Restoration of Natural Hair Color in Patient with Alopecia Areata Due to Psychological Disorder Using Exosomes: Case Report with 6-Month Follow-Up

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Exosome therapy successfully regrew and restored natural hair color in a man with stress-related hair loss.

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Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

research Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

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