Exosomes Mediate Sensory Hair Cell Protection in the Inner Ear

    May 2020 in “ Journal of Clinical Investigation ”
    Andrew M. Breglio, Lindsey A. May, Melanie Barzik, Nora C Welsh, Shimon P. Francis, Tucker Costain, Lizhen Wang, D. Eric Anderson, Ronald S. Petralia, Ya-Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham
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    TLDR Exosomes are crucial for protecting sensory hair cells in the inner ear.
    In 2020, researchers conducted a study using various strains of mice to explore the role of exosomes in protecting sensory hair cells in the inner ear. They used a range of techniques including heat shock, nanoparticle tracking analysis, exosome purification, and transmission electron microscopy. They also applied exogenous exosomes and inhibited exosome biogenesis pharmacologically. The study involved a significant number of utricles (9 to 44 per experiment), and the experiments were repeated multiple times for accuracy. The study concluded that exosomes play a crucial role in protecting sensory hair cells in the inner ear.
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